| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227152 | Tetrahedron | 2009 | 11 Pages |
Abstract
This report describes detailed studies of the scope and mechanism of a new Pd-catalyzed oxidation reaction for the stereospecific conversion of enynes into cyclopropyl ketones. Unlike related PdII/0, Au, and Pt-catalyzed cyclopropane-forming reactions, these transformations proceed with net inversion of geometry with respect to the starting alkene. This result, along with other mechanistic data, is consistent with a PdII/IV mechanism in which the key cyclopropane-forming step involves nucleophilic attack of a tethered olefin onto a PdIV–C bond.
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Physical Sciences and Engineering
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