| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227184 | Tetrahedron | 2006 | 6 Pages |
Abstract
Atorvastatin undergoes a self-sensitized photooxygenation by sunlight in water. The main photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. They present a pyrrol-2(3H)-one system arising from an oxidation of pyrrole ring and an alkyl/aryl shift. A mechanism involving singlet oxygen addition and an epoxide intermediate is suggested.
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Authors
Flavio Cermola, Marina DellaGreca, Maria Rosaria Iesce, Sara Montanaro, Lucio Previtera, Fabio Temussi,