| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227208 | Tetrahedron | 2007 | 6 Pages |
Abstract
Antimony(III) chloride (20 mol %) in refluxing acetonitrile efficiently catalyses the synthesis of dihydropyrimidinones (50-90% yields) by the Biginelli reaction of aromatic aldehydes, acetoacetate esters and urea. This reaction proceeds through 3-ureido-crotonates followed by cyclisation with an aromatic aldehyde to the dihydropyrimidinone.
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Authors
Ivica Cepanec, Mladen LitviÄ, Mirela Filipan-LitviÄ, Ivana Grüngold,