Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227255 | Tetrahedron | 2009 | 6 Pages |
Abstract
Five novel prenylated polyketides, harrisotones A-E (1-5) representing a rare spirocyclic skeleton, along with a new hydroperoxypolyketide harrisonol A (6), were isolated from the stems and leaves of Harrisonia perforata. The structures of harrisotones A-E (1-5) were extensively elucidated on the basis of spectroscopic analysis, especially 2D NMR and CD spectra. A plausible origin of compounds 1-5 was rationalized biogenetically, and traced back to harrisonol A (6). Harrisotones A-C (1-3) and harrisonol A (6) exhibited significant cytotoxicity against P-388 and/or A-549 tumor cell lines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sheng Yin, Xin Chen, Zu-Shang Su, Sheng-Ping Yang, Cheng-Qi Fan, Jian Ding, Jian-Min Yue,