Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227260 | Tetrahedron | 2009 | 5 Pages |
Abstract
A novel and improved synthetic route for the preparation of the new alkaloid setigerine, isolated from Papaver setigerum DC, and some new 3,4-dihydropapaverine and papaverine derivatives is reported. This method is based on the side chain chlorination of 1-benzyl-3,4-dihydroisoquinolines using N-chlorosuccinimide (NCS) and subsequent reaction with sodium methoxide in methanol to give the corresponding isoquinolines.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jan Jacobs, Nguyen van Tuyen, Peter Markusse, Christian V. Stevens, Leendert Maat, Norbert De Kimpe,