| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227273 | Tetrahedron | 2009 | 9 Pages |
Abstract
Gold-catalyzed nucleophilic substitution of propargylic alcohols with various nucleophiles (allylsilane, electron-rich aromatics, alcohols, thiols, hydrides, 1,3-dicarbonyl derivatives, sulfonamides) is described under very mild conditions (room temperature in dichloromethane). Preliminary mechanistic investigations suggest a mechanism through a carbocation intermediate. Nucleophilic substitutions on allylic and benzylic alcohols are also described.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marie Georgy, Valérie Boucard, Olivier Debleds, Christophe Dal Zotto, Jean-Marc Campagne,