| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227280 | Tetrahedron | 2009 | 24 Pages |
Abstract
The gold-catalyzed cycloisomerizations of 1,6-ene-ynamides proceed under mild conditions and lead to cyclobutanones from terminal or trimethylsilyl substituted ynamides, or to carbonyl compounds bearing a 2,3-methanopyrrolidine subunit from substrates possessing a propargylic alcohol moiety. High diastereoselectivities are observed with 1,6-ene-ynamides having a stereocenter at the α or β position of the nitrogen atom.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sylvain Couty, Christophe Meyer, Janine Cossy,