| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227339 | Tetrahedron | 2007 | 8 Pages |
Abstract
Simple mixing of chiral amines and surfactant Brønsted acids such as p-dodecyl benzenesulfonic acid (DBSA) leads to highly effective and selective organocatalysts in water. The in situ generated catalysts catalyze highly stereoselective desymmetrization of prochiral ketones via direct aldol reactions (up to >16:1 dr, >99% ee) in water using micelle as reaction media. The current strategy was also applied in asymmetric Michael addition leading to a catalytic system with good activity and stereoselectivity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
