| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227455 | Tetrahedron | 2008 | 6 Pages |
Abstract
A short and efficient procedure for the preparation of (R)-arundic acid, a therapeutic agent for the treatment of Alzheimer's disease, has been developed. Based on cheap and commercially available (1R)-(+)-camphor as the source of chiral information, (R)-arundic acid is synthesized in a four-step cyclic sequence with 55% overall yield and high optical purity, â¥98% ee. Alkyl halide and acetylene constitute the only consumable carbon sources of this method, which allows obtaining of both enantiomers and recycling of chiral auxiliary.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jesús M. GarcÃa, José M. Odriozola, Ainara Lecumberri, Jesús Razkin, Alberto González,