| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227462 | Tetrahedron | 2008 | 8 Pages |
Abstract
A new general synthetic route to obtain highly functionalized (Z)- and (E)-alk-1-enyl halides is described, where the halogen can be indistinctly F, Cl, Br, and I. The procedure involves CrCl2-promoted reductive elimination of β-O-substituted gem-dihalo alditols easily accessible from carbohydrates. The simplicity and mildness of the reaction conditions and their compatibility with different functional groups increase the synthetic potential of this methodology.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Elisa I. León, Nieves R. Paz, Concepción Riesco-Fagundo, Ernesto Suárez,