Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227493 | Tetrahedron | 2006 | 6 Pages |
Abstract
Malbrancheamide (1) is a novel indole alkaloid whose structure was unequivocally established by NMR, MS and X-ray studies. It caused moderate inhibition of radicle growth of Amaranthus hypochondriacus (IC50=0.37 μM) and inhibited the activation of the calmodulin (CaM)-dependent enzyme PDE1 (IC50=3.65±0.74 μM). The inhibition mechanism was competitive with respect to CaM according to a kinetic analysis (Ki=47.4±5.63 μM).
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Authors
Sergio MartÃnez-Luis, Rogelio RodrÃguez, Laura Acevedo, MarÃa C. González, Alfonso Lira-Rocha, Rachel Mata,