Synthesis of original thiazoloindolo[3,2-c]quinoline and novel 8-N-substituted-11H-indolo[3,2-c]quinoline derivatives from benzotriazoles. Part I

Synthesis of novel thiazoloindolo[3,2-c]quinoline and 8-substituted-11H-indolo[3,2-c]quinolines was performed via Graebe-Ullmann thermal cyclization from appropriated N-arylated benzotriazoles. 7H-4,7-Diaza-benzo[de]anthracene, a by-product reaction structurally closed to pyridoacridine skeleton was also identified.

The synthesis of original thiazoloindolo[3,2-c]quinoline and quinolinoquinoline rings system was investigated from benzotriazoles following a microwave-assisted Graebe-Ullmann cyclization.Download full-size image