Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227527 | Tetrahedron | 2007 | 7 Pages |
Abstract
The regioselective three-component condensation reaction of 2-hydroxy-1,4-naphthoquinone with isocyanides in the presence of a variety of aldehydes offers an easy one-pot access to linear naphtho[2,3-b]-furan-4,9-dione derivatives. This method has the advantage of good yields, high regioselectivity, and uses readily accessible substrates and reagents. The elucidation of regiochemistry has been accomplished by X-ray determination of some representative compounds.
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