| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227623 | Tetrahedron | 2007 | 9 Pages |
Abstract
A total synthesis of dolastatin 10, a potent inhibitor of microtubule assembly, which displayed remarkable antineoplastic activity, is reported. Our synthetic approach was based upon ruthenium-promoted asymmetric hydrogenation of β-keto esters derived from (S)-Boc-proline and (S)-Boc-isoleucine for the construction of the two key units: (2R,3R)-Boc-dolaproine (Dap) and (3R)-Boc-dolaisoleucine (Dil).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Céline Mordant, Sébastien Reymond, Hitoshi Tone, Damien Lavergne, Ridha Touati, Bechir Ben Hassine, Virginie Ratovelomanana-Vidal, Jean-Pierre Genet,