'Click chemistry' in CuI-zeolites: a convenient access to glycoconjugates

Zeolites modified with CuI ions are efficient catalyst for 'click' reactions involving carbohydrates and aminoacid derivatives. Glycopeptides and oligosaccharides mimics as well as multivalent carbohydrate derivatives have been obtained in good to high yield using heterogeneous CuI-modified zeolite catalysts. Contrarily to expectation, pore sizes and internal shapes within zeolites were not a limitation and large glucosyl ditriazoles, disaccharide triazoles, and glucosylated triazolylaminoacids could easily be obtained. Such CuI-zeolite heterogeneous catalysts greatly facilitated products recovery, through an easy filtration-solvent evaporation sequence, thus offering a convenient alternative to current methods.

Graphical abstractDownload full-size imageGlycopeptides and oligosaccharides mimics as well as multivalent saccharide derivatives have been obtained in high yields using heterogeneous CuI-modified zeolites as catalysts.