| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227817 | Tetrahedron | 2008 | 5 Pages |
Abstract
An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Márton Csékei, Zoltán Novák, András Kotschy,