Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227841 | Tetrahedron | 2007 | 9 Pages |
Abstract
The regioselectivity of the addition reaction of MeOH both in the condensed phase (MeOH/H2SO4) and in the gas-phase (MeOH/D3+) was examined in a series of activated aziridines. The results indicate that gas-phase operating conditions are particularly favorable for the occurrence of D+-mediated chelated bidentate species, which influence the regioselectivity of the opening process. In the condensed phase, the chelating MeOH/LiClO4 protocol turned out to be decidedly less effective for regioselectivity and also in determining the composition of the reaction mixture.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paolo Crotti, Gabriele Renzi, Graziella Roselli, Valeria Di Bussolo, Sandra Giuli, Sofia Tsitsigia, Maria Rosaria Romano,