| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5227858 | Tetrahedron | 2007 | 7 Pages |
Abstract
The chemistry of 1,2,3,4-tetrahydro-1,5-naphthyridines and 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepines has been explored with the goal of discovering reactions at N1 suitable for library development. Epoxide openings, Pd-catalyzed N-arylations, DEPBT-promoted acylations, and urea formation through the reaction with isocyanates were all successful. The epoxide opening chemistry using homochiral epichlorohydrin followed by epoxide reclosure and a second nucleophilic opening led to the preparation of a small 24-membered library.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Grace H.C. Woo, Aaron B. Beeler, John K. Snyder,