Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227923 | Tetrahedron | 2006 | 14 Pages |
Abstract
Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jérôme Quintin, Catherine Roullier, Sylviane Thoret, Guy Lewin,