Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5227975 | Tetrahedron | 2005 | 5 Pages |
Abstract
A polymeric scaffold with excellent swelling properties in organic and aqueous environments is highly desirable for the medicinal chemist. Here, we demonstrate that a cross-linked polyacrylamide hydrogel that displays large swelling properties in both organic solvent and water can serve as a scaffold for the photosensitizer hematoporphyrin. Upon exposure to light, the resulting resin efficiently generates singlet oxygen which can then react with appropriate substrates.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claude J. Rogers, Tobin J. Dickerson, Paul Jr., Kim D. Janda,