Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5228024 | Tetrahedron | 2007 | 10 Pages |
Abstract
Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stéphane Sengmany, Erwan Le Gall, Cédric Le Jean, Michel Troupel, Jean-Yves Nédélec,