Stereocontrolled reduction of chiral pyrrolidine and piperidine β-enamino esters: formal enantioselective synthesis of (+)-calvine

The results of a study dealing with the chemio- and diastereoselective reduction of chiral pyrrolidine and piperidine β-enamino esters 1, 2 and 3, 4 into β-amino esters are reported. This approach was successfully applied to a formal synthesis of (+)-calvine.

Graphical AbstractDownload full-size image