Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5228189 | Tetrahedron | 2008 | 9 Pages |
Abstract
The first, concise total synthesis of (±)-tensyuic acids B, C, and E, using chemoselective formal SN2Ⲡtype Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (±)-tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosoma brucei brucei strain GUTat 3.1.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takanori Matsumaru, Toshiaki Sunazuka, Tomoyasu Hirose, Aki Ishiyama, Miyuki Namatame, Takashi Fukuda, Hiroshi Tomoda, Kazuhiko Otoguro, Satoshi Åmura,