| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5228281 | Tetrahedron | 2005 | 7 Pages |
Abstract
An efficient synthesis of a potent PDE IV inhibitor 1 is described. The synthesis is highlighted by two practical and efficient catalytic reactions: a highly selective catalytic palladium mediated carbonylation of the pyridine side chain and an efficient palladium-catalyzed Suzuki-Miyaura coupling of a chloropyridine-N-oxide.
An efficient synthesis of a potent PDE IV inhibitor 1 is described. The synthesis is highlighted by two practical and efficient catalytic reactions: a highly selective catalytic palladium mediated carbonylation of the pyridine side chain and an efficient palladium-catalyzed Suzuki-Miyaura coupling of a chloropyridine-N-oxide.Download full-size image
Related Topics
Physical Sciences and Engineering
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Authors
Jennifer Albaneze-Walker, Jerry A. Murry, Arash Soheili, Scott Ceglia, Shawn A. Springfield, Charles Bazaral, Peter G. Dormer, David L. Hughes,