Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5228340 | Tetrahedron | 2008 | 10 Pages |
Abstract
The formal total synthesis of (â)-spongidepsin is described. Three fragments I, II, and III were first prepared from readily available starting materials and then assembled to the target compound. The key steps involved in the synthesis are asymmetric α-hydroxylation, Ender's alkylation, and ring-closing metathesis reactions. An alternative route for the fragment II is also achieved involving Sharpless asymmetric epoxidation and Gilman's alkylation as key reactions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
S. Chandrasekhar, S.R. Yaragorla, L. Sreelakshmi, Ch. Raji Reddy,