| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5228415 | Tetrahedron | 2008 | 7 Pages |
Abstract
A new approach to N1-C3 bridged macrocyclic β-lactams has been developed. Orthogonal functional groups' protection combined with RCM has allowed the construction of the bicyclic systems bearing a β-lactam motif. These systems could represent a structural alternative to the actual lactamic antibiotics and may be further transformed into a broad variety of compounds.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Miguel A. Sierra, Mamen RodrÃguez-Fernández, MarÃa José Mancheño, Luis Casarrubios, Mar Gómez-Gallego,