| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5228663 | Tetrahedron | 2007 | 9 Pages |
Prins-type cyclization followed by palladium-catalyzed cyclization provided sterically congested bi- or tricyclic tetrahydrofurans, which are very stereoselective as well. cis-2,5-Disubstituted tetrahydrofurans obtained from Prins-type cyclization have an allenyl group and a functional group such as alcohol, carboxylic acid, and aryl halide. The tetrahydrofurans bearing an allene group underwent palladium-catalyzed cyclization to give sterically congested bi- or tricyclic tetrahydrofurans.
Graphical abstractDownload full-size imagePrins-type cyclization followed by palladium-catalyzed cyclization provides a very good methodology for the synthesis of various sterically congested bicyclic tetrahydrofurans, which are very stereoselective as well.
