Article ID Journal Published Year Pages File Type
5228758 Tetrahedron 2008 11 Pages PDF
Abstract

A novel approach to the highly functionalized taxane ABC ring system through chemical conversion of the C19-diterpenoid alkaloid deltaline (1) was achieved in six steps (1→17) in 18% overall yield mainly by Grob fragmentation, fission of the Δ9(14) double bond, followed by aldol condensation, and Pelletier's cleavage process.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry