| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5228883 | Tetrahedron | 2008 | 7 Pages |
Abstract
A novel method for the synthesis of 5-arylmethylisoxazolidines via palladium-catalyzed reactions of aryl bromides with N-homoallylhydroxylamines is described. This reaction effects intramolecular C-O bond formation with concomitant intermolecular formation of a C-C bond in moderate to good yields. Moderate to excellent diastereoselectivities are observed for the formation of the isoxazolidines. The catalytic system has a tolerance to a wide variety of functional groups.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dahong Jiang, Jinsong Peng, Yuanwei Chen,