An efficient convergent synthesis of adenosine-5′-N-alkyluronamides

Herein we report a concise synthesis of adenosine-5′-alkyluronamides in which an enzyme-mediated deacetylation reaction was the key step in the selective modification of the 5′-position of the ribose unit, prior to a microwave-assisted ribose-purine coupling reaction and ultimately 5′-carboxamide formation with concomitant deprotection.