| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5228916 | Tetrahedron | 2008 | 7 Pages |
Abstract
Incorporation of (2S,3S)-4,4,4-trifluorothreonine (F3-Thr) instead of Thr in the enkephalin-derived hexapeptide led to the apparent conformational alteration due to the strong electron-withdrawing effect of the trifluoromethyl group by comparison with the original compound on the basis of their various NMR measurements.
Graphical abstractIncorporation of F3-Thr instead of Thr in the target hexapeptide 2 led to the apparent conformational alteration due to the strong electron-withdrawing effect of the CF3 group which was unambiguously clarified by comparison of their various NMR measurement results. Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takamasa Kitamoto, Shunsuke Marubayashi, Takashi Yamazaki,