| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5228943 | Tetrahedron | 2008 | 6 Pages |
Abstract
Expansion of DNA repeat sequences is associated with many human genetic diseases. Bulged DNA structures have been implicated as intermediates in DNA slippage within the DNA repeat regions. Two new binaphthol aminosugars were first synthesized as DNA bulge binders to study the triplet repeat expansion due to the wedge-shaped structure of 1,1â²-bi-2-naphthol. Both compounds were structurally characterized by 1- and 2-D NMR. They showed remarkable fluorescence enhancement when binding with bulge DNA and they exhibited stimulation for ATT·AAT trinucleotide repeat DNA sequence slippage synthesis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Liangliang Liu, Long Yi, Xing Yang, Zhihong Yu, Xin Wen, Zhen Xi,