| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5229077 | Tetrahedron | 2008 | 7 Pages |
Abstract
The Negishi cross-coupling reaction of organozinc iodides derived from α-amino acids with aromatic bromides to give substituted phenylalanine derivatives is described, using either Pd(OAc)2 or Pd2(dba)3 in combination with P(o-Tol)3 as catalyst in DMF at 50 °C. Similar results are obtained using Pd[PtBu3]2 as catalyst. The difference in reactivity displayed between aryl iodides and bromides (ArI>ArBr) has been utilised in a short synthesis of an unsymmetrical, orthogonally protected para-phenylene bis-alanine derivative.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claire L. Oswald, Tomás Carrillo-Márquez, Lorenzo Caggiano, Richard F.W. Jackson,