Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5229104 | Tetrahedron | 2008 | 11 Pages |
Abstract
Guided by protein structure similarity clustering (PSSC), a 483-member compound library was synthesized based on the decalin core moiety of the naturally occurring Cdc25A (red) inhibitor dysidiolide 1 as 'leitmotif' yielding novel acetylcholinesterase (AChE, blue) inhibitors.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael Scheck, Marcus A. Koch, Herbert Waldmann,