| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5229206 | Tetrahedron | 2007 | 7 Pages |
Abstract
Highly electrophilic dichlorofluoromethyl aryl ketones were obtained by oxidation of dichlorofluoromethyl aryl alcohols. Subsequent dechlorination of these ketones using sodium formaldehyde sulfoxylate (Rongalite) and reductive dehalogenating system SnCl2/Al led to various fluoromethyl aryl ketones and chlorofluoromethyl aryl ketones, respectively. Asymmetric reductions of these fluorinated ketones using the inexpensive baker's yeast produced the corresponding fluoromethyl aryl alcohols with different enantioselectivities.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Balaka Barkakaty, Yutaka Takaguchi, Sadao Tsuboi,