Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5229416 | Tetrahedron | 2007 | 8 Pages |
Abstract
Antiosteoporotic diarylheptanoids (â)-diospongins A (1) and B (2) were synthesized stereoselectively. The key steps in the synthesis include a stereospecific PdII-catalyzed cyclization of chiral 1,5,7-trihydroxy-2-heptenes, 6a and 6b, to form cis and trans tetrahydropyran rings and a regioselective Wacker oxidation of β-(tetrahydro-2H-pyran-2-yl)styrenes, 5a and 5b. Their C-5 epimers 3 and 4 were also synthesized.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobuyuki Kawai, Sudhir Mahadeo Hande, Jun'ichi Uenishi,