Investigation of macrocyclization sites for the synthesis of dendroamide A-an approach from a conformational search

The systematic conformational analysis of three linear precursors for the synthesis of dendroamide A has revealed that these three precursors have the distance between the N- and C-terminal in the range of 3.43-3.93 Å, which suggests the possibility of macrocyclization. This result coincides with the results of the actual synthesis of dendroamide A, but contradicts the reported calculated results.

Graphical abstractDownload full-size imageFrom a detailed conformational analysis, three precursors of dendroamide A have the distance between the N- and C-terminals in the range of 3.43∼3.93 Å which suggests the possibility of macrocyclization.