Convergent synthesis of PAMAM dendrimers using click chemistry of azide-functionalized PAMAM dendrons

Azide-functionalized PAMAM dendrons were synthesized by the divergent method using azidopropylamine as an azide focal point and applied for the construction of symmetric PAMAM-like dendrimers containing 1,2,3-triazole rings as connectors via stitching with two multi-terminal alkynes. The stitching method was based on the click chemistry protocol, i.e., the copper-catalyzed cycloaddition reaction between an alkyne and an azide.