Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5230156 | Tetrahedron | 2007 | 9 Pages |
Abstract
It was found that 2â²-O-cyanoethyl group could be removed from 2â²-O-cyanoethylated ribonucleoside derivatives by treatment with Bu4NF. This finding was successfully applied to the synthesis of oligoribonucleotides via their 2â²-O-cyanoethylated derivatives as key intermediates where a cyanoethyl group was used as the 2â²-hydroxyl protecting group. The rate of condensation using this protecting group in the presence of various activators was generally faster than that observed when a TBDMS group was used as the protecting group.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hisao Saneyoshi, Kaori Ando, Kohji Seio, Mitsuo Sekine,