Article ID Journal Published Year Pages File Type
5230233 Tetrahedron 2007 12 Pages PDF
Abstract
An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant 7 derived from sodium borohydride and d-(−)- or l-(+)-tartaric acid is developed. The methodology was applied for the preparation of bioactive products: 2,3-epoxyphosphonates, 2,3-aziridinophosphonates, phospho-GABOB, phospho-carnitine, etc.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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