Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5230399 | Tetrahedron | 2007 | 13 Pages |
Abstract
3-(Fluoroacyloxy)quinoline-2,4(1H,3H)-diones react with triethyl phosphite to afford either the product of the Perkow reaction or the corresponding 4-ethoxyquinolin-2(1H)-one. In both reactions, the fluorocarboxylate anion acts as the leaving group. For the corresponding 3-(fluoroiodoacetoxy) derivative this observation precludes the application of the intramolecular Wittig-Horner synthesis to modify quinoline-2,4(1H,3H)-diones by the annulation of a fluorinated but-2-enolide moiety.
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Authors
Karel Pomeisl, Jaroslav KvÃÄala, OldÅich Paleta, AntonÃn Klásek, Stanislav Kafka, Vladislav Kubelka, Jaroslav HavlÃÄek, Jan Äejka,