Article ID Journal Published Year Pages File Type
5230575 Tetrahedron 2007 8 Pages PDF
Abstract

Chiral five-membered ring 2-oxazolidinones and six-membered ring 1,3-oxazinan-2-ones are synthesized from the corresponding amino alcohols with complete inversion or retention of stereochemistry. Chiral 5-substituted 2-oxazolines and 6-substituted 2-oxazines are also synthesized from the same starting materials with inversion of stereochemistry through an intramolecular SN2 reaction. These compounds are useful intermediates in organic synthesis and crucial building blocks for many pharmaceutical compounds.

Graphical abstractDownload full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, ,