Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5230635 | Tetrahedron | 2006 | 7 Pages |
Abstract
Results of the optimized conditions for the one-pot synthesis of 2-substituted indoles via palladium acetate catalyzed tandem Sonogashira coupling 5-endo-dig cyclization at room temperature under ultrasonic irradiation and standard stirred conditions are described. Electron-donating and electron-withdrawing groups present in both coupling partners were well tolerated under these mild conditions. A copper-, ligand- and amine-free condition is an important feature of this protocol. Significant enhancement of reaction rates was observed for the reactions employing ultrasonic irradiation.
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Organic Chemistry
Authors
Sanjay S. Palimkar, P. Harish Kumar, Rajgopal J. Lahoti, Kumar V. Srinivasan,