Article ID Journal Published Year Pages File Type
5232452 Tetrahedron 2005 6 Pages PDF
Abstract

A new method for the solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines has been developed. The synthesis utilizes solid-phase bound 6-hydroxy-2,4-dichloroquinazoline as a key intermediate. Sequential substitution of the two chlorines furnishes the title compounds regioselectively with high purity. A library of 18×22 compounds demonstrates the general utility of this approach.

NR1R2=primary or secondary aliphatic amines, NR3R4=secondary aliphatic amines.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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