Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5232452 | Tetrahedron | 2005 | 6 Pages |
Abstract
A new method for the solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines has been developed. The synthesis utilizes solid-phase bound 6-hydroxy-2,4-dichloroquinazoline as a key intermediate. Sequential substitution of the two chlorines furnishes the title compounds regioselectively with high purity. A library of 18Ã22 compounds demonstrates the general utility of this approach.
NR1R2=primary or secondary aliphatic amines, NR3R4=secondary aliphatic amines.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Csaba Wéber, Attila Bielik, Ádám Demeter, István Borza, Györgyi I. Szendrei, György M. Keserű, István Greiner,