Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5233086 | Tetrahedron | 2005 | 7 Pages |
Abstract
Five new lyngbyabellin analogs along with a known compound, dolabellin, have been isolated from the marine cyanobacterium Lyngbya majuscula collected from Papua New Guinea. The structures of lyngbyabellins E-I were elucidated through extensive spectroscopic analysis, including HR-FABMS and 1D and 2D NMR experiments. The absolute configurations of lyngbyabellin E and H were ascertained by chiral HPLC and GC/MS analysis of degradation products, in combination with NMR experiments. All five lyngbyabellins showed cytotoxicity to NCI-H460 human lung tumor and neuro-2a mouse neuroblastoma cell lines with LC50 values between 0.2 and 4.8 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bingnan Han, Kerry L. McPhail, Harald Gross, Douglas E. Goeger, Susan L. Mooberry, William H. Gerwick,