Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5233347 | Tetrahedron | 2005 | 8 Pages |
Abstract
4a-Hydroxycycloalkyl[1,2-e]oxazolo[3,2-a]pyrimidin-9-ones 2 were synthesized from ethyl 2-oxocyclohexanecarboxylate by an one-step cyclocondensation from the 2-amino-2-oxazolines 1a-c in ethanol at room temperature, and easily dehydrated to provide oxazolo[3,2-a]pyrimidin-9-ones 3. In refluxing xylene, the reaction conducted with various ethyl 2-oxocycloalkanecarboxylates led to the two isomeric oxazolo[3,2-a]pyrimidinones 3 and 4.
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Authors
Ouro-Sama Adetchessi, Jean-Michel Léger, Jean Guillon, Isabelle Forfar-Bares, Jean-Jacques Bosc, Christian Jarry,