Efficient palladium catalysts for the amination of aryl chlorides: a comparative study on the use of phosphium salts as precursors to bulky, electron-rich phosphines

Aryl and heteroaryl chlorides are efficiently coupled with amines in the presence of Pd(OAc)2 and diadamantylphosphonium salts to give aryl amines in high yield (75-99%) and selectivity.