| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5234608 | Tetrahedron | 2005 | 7 Pages |
Abstract
The naturally occurring 3-acyltetramic acids (3-acylpyrrolidine-2,4-diones) melophlin A, B, C and G were prepared in few steps from α-aminoesters or their hydrochlorides by cyclization with Ph3PCCO under mild conditions. The employment of immobilized, polystyrene-bound ylide greatly simplifies the removal of by-product Ph3PO and of other impurities. Various 3-acylation methods were assessed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rainer Schobert, Carsten Jagusch,