Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5234613 | Tetrahedron | 2005 | 11 Pages |
Abstract
A practical, efficient and diastereoselective synthesis of the cytotoxic and antiprotozoal compound aculeatin D (1) is described, employing a biomimetic oxidative cyclisation cascade reaction to generate the tricyclic system of the natural product. The synthesis proceeds in ten steps from commercially available 1-tetradecanol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jack E. Baldwin, Robert M. Adlington, Victoria W.-W. Sham, Rodolfo Marquez, Paul G. Bulger,