Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
52368 | Catalysis Communications | 2008 | 5 Pages |
Abstract
The optically active orthopalladated phenanthrylamine phase transfer catalyst has been produced and explored for asymmetric glycine alkylation. The catalyst (10 mol%) in toluene/chloroform with 50% aqueous KOH (25 °C) promoted benzylation of benzophenone imine tert-butyl glycine. The product was obtained in 85% yield and 15% enantiomeric excess (ee). Addition of the chiral ionic liquid N,N-dimethyl ephedrinium bis(trifluoromethansulfon)imidate enhanced reactivity and selectivity for PTC glycine alkylation. It appears that the chiral ionic liquid has a cooperative effect to boost the ee content of an asymmetric reaction.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Deb Kumar Mukherjee, Nripendranath Ghosh,